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Objective To investigate the clinical efficacy and safety of triclosan in combination with compound glycyrrhizin in the treatment of chronic urticaria. Methods A total of 100 patients with chronic urticaria who were enrolled in our hospital from December 2014 to December 2015 were divided into control group and observation group by random number table method,with 50 cases in each group. The control group was given desloratadine alone, and the observation group was treated with on the basis of the addition of compound glycyrrhizin tablets adjuvant therapy.compare the two groups of patients withThe short-term efficacy,the scores of 7 days urticaria activity,the laboratory indicators and the rate of follow-up recurrence were compared before and after treatment in two groups. Results The total effective rate (96.00％) of the observation group was significantly higher than that of the control group (76.00％) (P <0.05). After the treatment of 7days, the urticaria and itching score in the observation group [(0.79 ± 0.20), (0.65 ± 0.10)] were significantly lower than the control group [(1.54 ± 0.29), (1.29 ± 0.42)] (P<0.05). The levels of IL-4, IFN-γ and IgE in the observation group [(28.16 ± 4.10) pg / mL, (11.95 ± 3.05) pg / mL, (55.21 ± 11.37 g / L) were significantly higher than those in the control group[(35.40 ± 7.92) pg/mL,(7.23 ± 1.89) pg/mL, (73.75 ± 15.09) g/L] (P<0.05). The recurrence rate (10.00％, 18.00％) in the observation group was significantly lower than that in the control group (24.00％, 36.00％) (P<0.05).Conclusion The treatment of chronic urticaria with cisplatin combined with compound glycyrrhizin can alleviate the symptoms of skin lesions, improve the level of related laboratory indicators and help to avoid long-term recurrence.
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Objective To evaluate traditional Chinese medicine (TCM ) formula granules of clear heat evil and detoxifica‐tion treating hyperuricemia clinical efficacy and safety through randomized ,placebo controlled ,blinded clinical trial .Methods 120 patients with hyperuricemia syndrome of damp heat and blood stasis were selected ,randomly divided into control and treat‐ment groups ,60 cases in each group ,in a period of 4 weeks of treatment and observation .The basic treatment was given to both two groups (diet ,exercise etc);in addition ,the control group had placebo while treatment group was given TCM clean heat evil and detoxifying formula granules .The clinical efficacy of the products was evaluated by compariment of TCM clinical symptoms before and after treatment as well as serum uric acid ,lipids (TC ,TG ,LDL‐C) ,fasting blood sugar ;meanwhile ob‐serving complete blood counts (CBC) ,liver function (ALT ,AST ) ,kidney function (BUN ,Cr) ,electrocardiogram (ECG) and adverse reactions to evaluate its safety .Results After 4 weeks of treatment with TCM clear heat evil and detoxifying formula granules ,the treatment group symptom total efficiency was 84% ,while the placebo control group symptom total efficiency was 25% ,the difference is significant statisticly (P<0 .001);the treatment group of TCM clean heat evil and detoxifying formula granules significantly reduced in the blood uric acid ,compared with before treatment (P<0 .01) ,as well as compared with the placebo control group (P<0 .05);after treatment the TCM clear heat evil and detoxifying formula granules significantly re‐duced in the LDL‐C level (P<0 .05) compared with before treatment .Comparing before treatment with after treatment ,there was no significant difference between the two groups ,in routine blood tests ,liver and kidney functions ,or ECG (P> 0 .05) . There were no side effects or adverse events in either groups in period of treatment and observation .Conclusion TCM clear heat evil and detoxifying formula granules is curative for the hyperuricemia and obviously improve the clinical symptoms for hy‐peruricemia in patients with damp heat and blood stasis .It is a safe and efficient formulation to reduce uric acid .
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Teacher Lian Jianwei is good at treating internal diseases,however he is experienced at nose diseases too by differentiating signs and looking into inside from outside;now 3 medical concerned cases are extracted for reference.
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This article discussed the author applied the thought of treatment based on syndrome differentiation that acquisitioned from following the master for many years.The three cases of experience in treating insomnia,welling-abscess of the lung and minor chest bind disease applying classical formulae of Xiaochaihu decoction,Weijing decoction and Xiaoxianxiong decoction separately all get preferable clinical curative effect.